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Defense Advanced Research Projects Agency

For more than fifty years, DARPA has held to a singular and enduring mission: to make pivotal investments in breakthrough technologies for national security.

The genesis of that mission and of DARPA itself dates to the launch of Sputnik in 1957, and a commitment by the United States that, from that time forward, it would be the initiator and not the victim of strategic technological surprises. Working with innovators inside and outside of government, DARPA has repeatedly delivered on that mission, transforming revolutionary concepts and even seeming impossibilities into practical capabilities. The ultimate results have included not only game-changing military capabilities such as precision weapons and stealth technology, but also such icons of modern civilian society such as the Internet, automated voice recognition and language translation, and Global Positioning System receivers small enough to embed in myriad consumer devices.

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Tauber Bioinformatics Research Center

The Tauber Bioinformatics Research Center was established at the University of Haifa based on a donation by the Laszlo N. Tauber Family Foundation. The Center is under the auspices of the Research Authority at the University of Haifa.

Bioinformatics of high-throughput “omics” data, consisting of genomics, transcriptomics, proteomics, and metabolomics, is a new revolutionary instrument of research and development in biology, medicine and agriculture. It deals with extremely large biological data sets and so requires advanced specialized algorithms optimized for working with huge databases of heterogeneous types of data. The Tauber Bioinformatics Research Center was established to develop scalable high performance computing (HPC) hardware/software solutions for existing and coming challenges of “big data” in biomedicine and agrobiology.

- Dr. Leonid Brodsky Haifa University
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UCSF Andino Lab

RNA viruses: replication, pathogenesis and evolution

RNA viruses are a major threat to human health and well-being. They also provide a fascinating window into cell biology and immunology, since they interact intimately with their hosts at both cellular and systemic levels. The constant interplay between viruses trying to establish infection and the host trying to control them presents an ideal system to study evolution in action. In the lab we are interested in understanding these diverse but interconnected aspects of RNA virus biology.

More information about what we do can be found in the Projects link.

- Dr. Raul Andino UCSF Andino Lab
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Stanford University

The long term goal of our research is to understand how proteins fold in living cells. The Frydman lab uses a multidisciplinary approach to address fundamental questions about molecular chaperones, protein folding and degradation. In addition to basic mechanistic principles, we aim to define how impairment of cellular folding and quality control are linked to disease, including cancer and neurodegenerative diseases and examine whether reengineering chaperone networks can provide therapeutic strategies.

- Dr. Judith Frydman Stanford University
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Pine Biotech

Pine Biotech is a company commercializing tools for high throughput data. The company is creating a high precision approach to analysis and integration of big biomedical data. Through ongoing collaborations with corporate and academic partners, high quality methods and machine learning tools are being developed and used to gain deep biological understanding of disease and health.

- Elia Brodsky Pine Biotech
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Cattaneo Lab, Mayo Clinic

Dr. Cattaneo’s team recently discovered why measles virus is extremely contagious: it uses a protein selectively expressed in the trachea to emerge from the host at a location facilitating aerosol droplet release through coughing and sneezing. Remarkably, nectin-4 is a marker for lung, breast and ovarian cancer, which has immediate consequences for ongoing measles-based cancer clinical trials.

The National Cancer Institute, the National Institute of Allergy and Infectious Diseases, and other national and international granting agencies fund Dr. Cattaneo’s research.

- Christian Pfaller Cattaneo Lab, Mayo Clinic
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